A lifespan-extending form of autophagy employs the vacuole-vacuole fusion machinery
نویسندگان
چکیده
منابع مشابه
A life-span extending form of autophagy employs the vacuole-vacuole fusion machinery.
While autophagy is believed to be beneficial for life-span extension, it is controversial which forms or aspects of autophagy are responsible for this effect. We addressed this topic by analyzing the life span of yeast autophagy mutants under caloric restriction, a longevity manipulation. Surprisingly, we discovered that the majority of proteins involved in macroautophagy and several forms of m...
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Yeast vacuoles undergo fission and homotypic fusion, yielding one to three vacuoles per cell at steady state. Defects in vacuole fusion result in vacuole fragmentation. We have screened 4828 yeast strains, each with a deletion of a nonessential gene, for vacuole morphology defects. Fragmented vacuoles were found in strains deleted for genes encoding known fusion catalysts as well as 19 enzymes ...
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T he yeast vacuole (similar to the lysosome in higher eukaryotes) is the recipient of cargo from both the secretory and endocytic pathways. Studies of this highly dynamic organelle have been crucial to our general understanding of intracellular transport, and Christian Ungermann continues to elucidate the many different steps of vacuole fusion and the proteins that regulate them. earned his PhD...
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ژورنال
عنوان ژورنال: Autophagy
سال: 2008
ISSN: 1554-8627,1554-8635
DOI: 10.4161/auto.6556